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ACE2?(2C1)?Mouse?Monoclonal?Antibody
AK96249
ACE2?(2C1)?Mouse?Monoclonal?Antibody
貨號(hào) 純度 規(guī)格 目錄價(jià) 會(huì)員價(jià) 庫存 數(shù)量 購(gòu)買
AK96249-100ul 50ul 50ul ￥1580.00 登錄查看
產(chǎn)品詳情

產(chǎn)品貨號(hào)

AK96249

別名

Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin

converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed

angiotensin-converting enzyme 2]

產(chǎn)品名稱

ACE2 (2C1) Mouse Monoclonal Antibody

類別

抗原抗體

基因名稱

ACE2 UNQ868/PRO1885

蛋白名稱

ACE2

推薦應(yīng)用

WB,IHC,IF

反應(yīng)種屬

Human,Mouse,Rat

濃度

1 mg/ml

制備方法

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope

specific immunogen.

存儲(chǔ)緩沖液

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

Human Gene ID

59272

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59272

Human Swissprot No.

Q9BYF1

Human Swissprot Link

https://www.uniprot.org/uniprotkb/Q9BYF1/entry

Mouse Gene ID

70008

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70008

Mouse Swissprot No.

Q8R0I0

Mouse Swissprot Link

https://www.uniprot.org/uniprotkb/Q8R0I0/entry

Rat Gene ID

302668

1 / 2Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302668

Rat Swissprot No.

Q5EGZ1

Rat Swissprot Link

https://www.uniprot.org/uniprotkb/Q5EGZ1/entry

特異性

This antibody detects endogenous levels of ACE2 at Human, Mouse,Rat

稀釋度

WB 1:500-2000, IHC 1:50-200, IF 1:50-200

參考分子量

120-135kD

運(yùn)輸及保存條件

-15°C to -25°C/1 year(Do not lower than -25°C)

細(xì)胞定位

[Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane ; Single-pass type I

membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both

cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane .

功能

cofactor:Binds 1 chloride ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,enzyme

regulation:Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu,

and EDTA, but not by the ACE inhibitors linosipril, captopril and

enalaprilat.,function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of

unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze

apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In

case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the

spike glycoprotein of both coronaviruses.,induction:Up-regulated in failing heart.,PTM:N

glycosylation on Asn-90 may limit SARS infectivity.,similarity:Belongs to the peptidase M2

family.,subunit:Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike

glycoprotein.,tissue specificity:Expressed in endothelial cells from small and large arteries, and in

arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small

intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and

gastrointestinal system.,

 

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