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“衰老關(guān)鍵蛋白”抗體
AK18552
Fibulin 1
Rabbit
(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse)
WB,IHC-P,IHC-F,IF,ELISA
多克隆
貨號(hào) 純度 規(guī)格 目錄價(jià) 會(huì)員價(jià) 庫(kù)存 數(shù)量 購(gòu)買
AK18552-50ul 50ul 50ul ￥1380.00 登錄查看
AK18552-100ul 100ul 100ul ￥2380.00 登錄查看
AK18552-200ul 200ul 200ul ￥3480.00 登錄查看
產(chǎn)品詳情

公司產(chǎn)品僅供科研研究實(shí)驗(yàn)，不得用于臨床！

商品詳情：

英文名稱：Fibulin 1
中文名稱：“衰老關(guān)鍵蛋白”抗體
別    名：Basement membrane protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1; Fibulin-1.  
研究領(lǐng)域腫瘤：  心血管  細(xì)胞生物  免疫學(xué)  內(nèi)分泌病  
抗體來源：Rabbit
克隆類型：Polyclonal
交叉反應(yīng)：(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用：WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量：74kDa
細(xì)胞定位：細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀：Liquid
濃    度：1mg/ml
免 疫 原：KLH conjugated synthetic peptide derived from human Fibulin 1: 501-600/703 
亞    型：IgG
純化方法：affinity purified by Protein A
緩 沖 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
產(chǎn)品介紹：Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.

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